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  • December 2003

    Sensitivity of CT Colonography vs Colonoscopy

    New England Journal of Medicine | Perry J. Pickhardt et al.

    Article:

    Computed Tomographic Virtual Colonoscopy to Screen for Colorectal Neoplasia in Asymptomatic Adults

    Authors:

    Perry J. Pickhardt, M.D.; J. Richard Choi, Sc.D., M.D.; Inku Hwang, M.D.; James A. Butler, M.D.; Michael L. Puckett, M.D.; Hans A. Hildebrandt, M.D.; Roy K. Wong, M.D.; Pamela A. Nugent, M.D.; Pauline A. Mysliwiec, M.D., M.P.H.; William R. Schindler, D.O.

    Journal:

    New England Journal of Medicine, 2003

    Summary:

    Researchers evaluated the performance characteristics of computed tomographic (CT) virtual colonoscopy for the detection of colorectal neoplasia in an average-risk screening population. A total of 1233 asymptomatic adults (mean age, 57.8 years) underwent same-day virtual and optical colonoscopy. Radiologists used the three-dimensional endoluminal display for the initial detection of polyps on CT virtual colonoscopy. Sensitivity and specificity of virtual colonoscopy and the sensitivity of optical colonoscopy were calculated with the use of the findings of the final, unblinded optical colonoscopy as the reference standard.

    Based on the study, Pickhardt et al concluded that, “CT virtual colonoscopy with the use of a three-dimensional approach is an accurate screening method for the detection of colorectal neoplasia in asymptomatic average-risk adults and compares favorably with optical colonoscopy in terms of the detection of clinically relevant lesions.”

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