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  • October 2007

    Benefits of MRI in Detecting Breast Cancer

    Clinical Cancer Research | Christopher C. Riedl et al.


    Magnetic Resonance Imaging of the Breast Improves Detection of Invasive Cancer, Preinvasive Cancer, and Premalignant Lesions during Surveillance of Women at High Risk for Breast Cancer


    Christopher C. Riedl; Lothar Ponhold; Daniel Flory; Michael Weber; Regina Kroiss; Teresa Wagner; Michael Fuchsjager; Thomas H. Helbich


    Clinical Cancer Research, October 15, 2007


    In this prospective comparison study, women at high risk for breast cancer were offered annual surveillance examinations, consisting of mammography, ultrasound, and MRI, at a single tertiary care breast center. The purpose of the study was to assess the diagnostic accuracy of mammography, ultrasound, and magnetic resonance imaging (MRI) of the breast in the surveillance of women at high risk for breast cancer. The sensitivity and specificity of each modalitywas based on the histopathologic evaluation of suspicious findings from all modalities plus the detected interval cancers.

    MRI detected significantly more invasive, as well as preinvasive cancers, than mammography and ultrasound. According to Riedl et al, “Our results show that MRI of the breast improves the detection of invasive cancers, preinvasive cancers, and premalignant lesions in a high-risk population and should therefore become an integral part of breast cancer surveillance in these patients.”

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